Upputuri S, Prasad S
Department of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Little France Cresent, Edinburgh, EH16 4SA, UK.
Clin Drug Investig. 2006;26(12):745-7. doi: 10.2165/00044011-200626120-00008.
A 62-year-old man with no drug allergies was admitted for coronary artery bypass grafting. Postoperatively, metoclopramide was commenced for the treatment of gastroparesis. Ten days after the drug was initiated a purpuric rash was noticed on his lower limbs. His platelet count was normal. Infection was excluded and the cause was not obvious. No change was noticed in the condition of rash despite discontinuation of all other medications started in the hospital one at a time. The rash later began to subside upon discontinuation of metoclopramide. A rechallenge was not attempted for ethical reasons. In conclusion, metoclopramide was considered to be the causative agent of this rash as it subsided after the discontinuation of metoclopramide.
一名62岁无药物过敏史的男性因冠状动脉旁路移植术入院。术后,开始使用甲氧氯普胺治疗胃轻瘫。用药10天后,发现其下肢出现紫癜样皮疹。他的血小板计数正常。排除了感染因素,病因不明。尽管一次停用了医院开始使用的所有其他药物,但皮疹情况未见变化。停用甲氧氯普胺后,皮疹后来开始消退。出于伦理原因,未进行再激发试验。总之,由于停用甲氧氯普胺后皮疹消退,故认为甲氧氯普胺是该皮疹的致病因素。