Muela Molinero A, Jorquera Plaza F, Ribas Ariño T, Malagón Rojo R, Espinel Diez V, Ballesteros del Río B, Olcoz Goñi J L, Santos Calderón J A
Services of Internal Medicine, León Hospital, Spain.
Rev Esp Enferm Dig. 2006 Dec;98(12):907-16. doi: 10.4321/s1130-01082006001200003.
We analyzed the characteristics of patients with gastric tumors diagnosed with multiple malignant primary neoplasm (MMPN) in the Health District of León.
Using the information in the Tumor Registry at León Hospital patients selected were those with gastric neoplasms diagnosed between 1993 and 2002. A follow-up was performed until December 31, 2004, and the characteristics of patients diagnosed with a second neoplasm were analyzed.
MMPN prevalence was 1,96%; 56% of patients had a history of cancer in first-degree relatives. The most frequent second neoplasms were digestive (26%) and urologic (21%); 87% of patients were diagnosed with a second neoplasm within the first two years. No significative differences in survival were observed among patients with synchronous or metachronous MMPN.
MMPN in patients with gastric neoplasms is a relevant problem. While external carcinogenic agents could act as promoters in the development of second neoplasms, these patients seem to have a genetic background favoring the development of MMPN. Secondary prevention is the best measure to avoid MMPN development.
我们分析了莱昂健康区诊断为多原发性恶性肿瘤（MMPN）的胃肿瘤患者的特征。
利用莱昂医院肿瘤登记处的信息，选取1993年至2002年间诊断为胃肿瘤的患者。随访至2004年12月31日，并分析诊断为第二种肿瘤的患者的特征。
MMPN患病率为1.96%；56%的患者一级亲属有癌症病史。最常见的第二种肿瘤是消化系统肿瘤（26%）和泌尿系统肿瘤（21%）；87%的患者在头两年内被诊断出第二种肿瘤。同步或异时性MMPN患者的生存率无显著差异。
胃肿瘤患者的MMPN是一个相关问题。虽然外部致癌因素可能在第二种肿瘤的发生中起促进作用，但这些患者似乎有有利于MMPN发生的遗传背景。二级预防是避免MMPN发生的最佳措施。
