Department of General Surgery, Medical Faculty of Abant Izzet Baysal University, Bolu, Turkey.
Radiol Oncol. 2010 Dec;44(4):239-43. doi: 10.2478/v10019-010-0048-2. Epub 2010 Nov 16.
The risk of developing a second primary tumour in patients with gastric carcinoma is higher than among the general population. The aim was to investigate the clinicopathological characteristics of the second primary cancers in patients with gastric cancer in this study.
In the retrospective study, patients with gastric cancers were evaluated between 1995 and 2005 for primary tumours according to Warren and Gates' criteria related with the second primary cancers.
Nine of the 112 patients with gastric cancer had second primary cancers. Seven of the patients were males and two females. Six patients with gastric cancers had synchronous, and three had metachronous tumours. The age of the patients ranged from 53 to 78 years, and the mean age was 61 ± 8.3 years. The most frequent site of occurrence of the second tumours was the colo-rectum (33%) followed by the upper respiratory system (22%), and the urogenital system (22%) in descending order of frequency.
The incidence of the second primary cancer in gastric cancer patients was 8% in the current report. It is recommended that careful preoperative and postoperative examinations for other primary cancers, as well as for the extent of the primary gastric carcinoma, are carried out. Because colorectal cancer was the most common carcinoma combined with gastric carcinoma, the surveillance for this carcinoma (e.g., colonoscopy, abdominopelvic CT) would be appropriate after the diagnosis of gastric carcinoma.
胃癌患者发生第二原发肿瘤的风险高于普通人群。本研究旨在探讨胃癌患者第二原发癌的临床病理特征。
在这项回顾性研究中，根据 Warren 和 Gates 标准，对 1995 年至 2005 年间的 112 例胃癌患者的原发性肿瘤进行了评估，与第二原发癌相关。
112 例胃癌患者中有 9 例发生第二原发癌。7 例为男性，2 例为女性。6 例胃癌患者为同步肿瘤，3 例为异时性肿瘤。患者年龄 53-78 岁，平均年龄 61±8.3 岁。第二肿瘤最常见的部位是结肠-直肠（33%），其次是上呼吸道（22%），按频率降序排列，还有泌尿生殖系统（22%）。
本报告中胃癌患者第二原发癌的发生率为 8%。建议对其他原发性癌症以及原发性胃癌的范围进行仔细的术前和术后检查。由于结直肠癌是最常见的与胃癌并存的癌，因此在诊断为胃癌后，对这种癌（例如结肠镜检查、腹盆腔 CT）进行监测是合适的。
