西班牙裔和非西班牙裔白人二尖瓣环钙化的患病率及临床相关性

Prevalence and clinical correlates of mitral annulus calcification in Hispanics and non-Hispanic whites.

作者信息

Willens Howard J, Chirinos Julio A, Hennekens Charles H

机构信息

Department of Medicine, Division of Cardiology, University of Miami Miller School of Medicine, Miami, Florida, USA.

出版信息

J Am Soc Echocardiogr. 2007 Feb;20(2):191-6. doi: 10.1016/j.echo.2006.08.010.

DOI:10.1016/j.echo.2006.08.010

PMID:17275706

Abstract

BACKGROUND

Data about mitral annulus calcification (MAC) are sparse in Hispanics. We compare prevalence and clinical correlates of MAC in Hispanics and non-Hispanic whites.

METHODS

We reviewed echocardiograms and clinical data of 337 Hispanics and 279 non-Hispanic whites, age 45 to 75 years. In cross-sectional data, prevalence and interrelationships of MAC, coronary heart disease (CHD), and risk factors were compared using multivariable logistic regression.

RESULTS

In Hispanics, MAC was significantly associated with CHD (odds ratio [OR] = 2.06, confidence interval [CI] = 1.09-3.87), age (OR = 1.73, CI = 1.21-2.49), female sex (OR = 1.87, CI = 1.01-3.47), smoking (OR = 1.80, CI = 1.01-3.24), and having multiple (>2) risk factors (OR = 3.43, CI = 2.66-4.43). In non-Hispanic whites, MAC was associated with CHD (OR = 4.24, CI = 2.00-8.98), age (OR = 2.87, CI = 1.82-4.50), and having multiple risk factors (OR = 3.59, CI = 2.7-4.77). There were no significant ethnic differences in prevalence of MAC.

CONCLUSIONS

Among Hispanics referred for echocardiography, MAC is associated with CHD and risk factors.

摘要

背景

西班牙裔人群中二尖瓣环钙化（MAC）的数据较少。我们比较了西班牙裔和非西班牙裔白人中MAC的患病率及临床相关性。

方法

我们回顾了337名年龄在45至75岁之间的西班牙裔和279名非西班牙裔白人的超声心动图及临床数据。在横断面数据中，使用多变量逻辑回归比较MAC、冠心病（CHD）及危险因素的患病率和相互关系。

结果

在西班牙裔人群中，MAC与CHD显著相关（比值比[OR]=2.06，置信区间[CI]=1.09-3.87）、年龄（OR=1.73，CI=1.21-2.49）、女性（OR=1.87，CI=1.01-3.47）、吸烟（OR=1.80，CI=1.01-3.24）以及存在多种（>2种）危险因素（OR=3.43，CI=2.66-4.43）。在非西班牙裔白人中，MAC与CHD（OR=4.24，CI=2.00-8.98）、年龄（OR=2.87，CI=1.82-4.50）以及存在多种危险因素（OR=3.59，CI=2.7-4.77）相关。MAC的患病率在种族间无显著差异。