Clarke-Moloney M, Godfrey A, O'Connor V, Meagher H, Burke P E, Kavanagh E G, Grace P A, Lyons G M
Department of Vascular Surgery, Midwestern Regional Hospital, Limerick, Ireland.
Eur J Vasc Endovasc Surg. 2007 Apr;33(4):488-93. doi: 10.1016/j.ejvs.2006.11.032. Epub 2007 Feb 2.
To compare mobility in patients with venous leg ulcers to matched controls and determine the influence of mobility, age and ulcer size on ulcer healing.
25 leg ulcer patients, and 25 matched controls wore a mobility monitor (ActivPAL, PAL Technologies Ltd, Glasgow, Scotland)) which recorded the number of steps and amount of time spent walking, standing, sitting or lying for a one-week period. A walking index was calculated. The ulcer group were treated with compression bandaging and ulcer healing recorded over 12 weeks.
There were 13 female subjects in each group. The median age was 70.5 (range 30-89) years. There was no difference in the amount of time either group spent standing, walking and resting. There was a significant reduction in the number of steps taken and in the walking index in the ulcer group compared to controls (ulcer group, median 6,685 steps/day, range 2074-17,999; control group median 8750, range 4917-16,043, p<0.05, Mann Whitney u test). Smaller ulcers and ulcers of recent onset were most likely to heal within 12 weeks (p=0.005 and p=0.011 respectively, Chi squared test). The percentage of time spent mobilising and resting did not influence ulcer healing (r(s)=-0.125; p=0.55).
Mobility patterns among patients with leg ulcers are not significantly different to age matched controls. Ulcer patients take fewer steps per week compared to controls indicating they have reduced calf muscle pump function. Further studies are required to determine whether therapies which increase calf muscle activity have a role in ulcer treatment.
比较下肢静脉溃疡患者与匹配对照组的活动能力,并确定活动能力、年龄和溃疡大小对溃疡愈合的影响。
25例下肢溃疡患者和25例匹配对照组佩戴活动监测器(ActivPAL,PAL Technologies Ltd,格拉斯哥,苏格兰),记录一周内的步数以及行走、站立、坐或躺的时间。计算步行指数。溃疡组采用加压包扎治疗,并记录12周内的溃疡愈合情况。
每组有13名女性受试者。中位年龄为70.5岁(范围30 - 89岁)。两组站立、行走和休息所花费的时间没有差异。与对照组相比,溃疡组的步数和步行指数显著降低(溃疡组,中位步数为每天6685步,范围2074 - 17999步;对照组中位步数为8750步,范围4917 - 16043步,p<0.05,曼-惠特尼U检验)。较小的溃疡和近期发病的溃疡最有可能在12周内愈合(分别为p = 0.005和p = 0.011,卡方检验)。活动和休息所花费时间的百分比不影响溃疡愈合(r(s)= -0.125;p = 0.55)。
下肢溃疡患者的活动模式与年龄匹配的对照组没有显著差异。与对照组相比,溃疡患者每周的步数较少,表明他们的小腿肌肉泵功能降低。需要进一步研究以确定增加小腿肌肉活动的治疗方法是否在溃疡治疗中起作用。