Lepercq J, Catalano P, Hauguel de Mouzon S
Service de Gynécologie-Obstétrique, Groupe Hospitalier Cochin-Saint-Vincent-de-Paul (APHP), 82, avenue Denfert-Rochereau, 75674 Paris cedex 14, France.
Gynecol Obstet Fertil. 2007 Feb;35(2):89-95. doi: 10.1016/j.gyobfe.2006.12.015. Epub 2007 Feb 2.
Leptin has been primarily considered as a protein secreted by the adipocyte and a regulator of satiety and energy homeostasis. A role for leptin in pregnancy was later suggested as circulating levels of leptin are high in the pregnant woman and leptin is synthetized within the placenta. Placental leptin production is increased in various obstetrical conditions associated with alterations of fetal growth (diabetes, preeclampsia). Furthermore, umbilical leptin can be viewed as a biomarker of fetal adiposity. Our aim is to review the putative roles of leptin in pregnancy.
瘦素主要被认为是一种由脂肪细胞分泌的蛋白质，是饱腹感和能量稳态的调节因子。后来有人提出瘦素在妊娠中的作用，因为孕妇体内瘦素的循环水平很高，且胎盘内可合成瘦素。在与胎儿生长改变相关的各种产科情况（糖尿病、先兆子痫）中，胎盘瘦素的产生会增加。此外，脐血瘦素可被视为胎儿肥胖的生物标志物。我们的目的是综述瘦素在妊娠中的假定作用。
