Russfield A B
Methods Achiev Exp Pathol. 1975;7:132-48.
Methods are described for maintaining hypophysectomized rats (model for panhypopituitarism). Prolactin-secreting pituitary tumors can be induced in rats or mice by administration of estrogens; thyroid stimulating hormone-secreting tumors will occur in some mice after thyroid ablation by radioactive iodine. Estrogens in hamsters usually produce intermediate lobe tumors of the pituitary associated with hypothalamic degeneration. Sex hormone-secreting adrenal tumors can follow surgical gonadectomy in mice. Spontaneous corticoid-secreting adrenal tumors may occur spontaneously in Osborne-Mendel rats. Secretory gonadal tumors have been induced by transplantation of a gonad into the spleen of a gonadectomized host. Both secretory and non-secretory ovarian tumors can be produced by irradiation or chemical carcinogens in mice. In some mice, secretory testicular tumors can be produced by estrogen administration. Thyroid tumors can be induced in rodents by various kinds of goitrogens and irradiation. Parathyroid hyperplasia may occur with spontaneous renal disease in rats. A syndrome simulating diabetes mellitus can occur in rare strains of mice or can be induced by chemical destruction of the islets of Langerhans with alloxan.
描述了维持垂体切除大鼠（全垂体功能减退模型）的方法。通过给予雌激素可在大鼠或小鼠中诱导分泌催乳素的垂体肿瘤；用放射性碘消融甲状腺后，一些小鼠会发生分泌促甲状腺激素的肿瘤。仓鼠中的雌激素通常会产生与下丘脑变性相关的垂体中间叶肿瘤。性激素分泌性肾上腺肿瘤可在小鼠接受性腺切除手术后出现。自发性分泌皮质类固醇的肾上腺肿瘤可能在奥斯本-孟德尔大鼠中自发发生。通过将性腺移植到性腺切除宿主的脾脏中可诱导分泌性性腺肿瘤。在小鼠中，辐射或化学致癌物可产生分泌性和非分泌性卵巢肿瘤。在一些小鼠中，给予雌激素可产生分泌性睾丸肿瘤。各种致甲状腺肿物质和辐射可在啮齿动物中诱导甲状腺肿瘤。大鼠自发性肾病可能会伴发甲状旁腺增生。模拟糖尿病的综合征可能出现在罕见品系的小鼠中，或可通过用四氧嘧啶化学破坏胰岛来诱导。
