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Nonneoplastic lesions of the ovary in Fischer 344 rats and B6C3F1 mice.

作者信息

Montgomery C A, Alison R H

机构信息

National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.

出版信息

Environ Health Perspect. 1987 Aug;73:53-75. doi: 10.1289/ehp.877353.

DOI:10.1289/ehp.877353
PMID:3665871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1474552/
Abstract

The National Toxicology Program's pathology database on 2-year carcinogenicity studies was reviewed for nonneoplastic ovarian disease. Ovaries from 39,941 female Fischer rats and 41,444 female B6C3F1 mice were examined. A variety of inflammatory, degenerative, vascular, and proliferative lesions were documented and are described. The most common ovarian lesions in rats were cysts (6%). The most frequent ovarian lesions in mice were cysts (15%), acute inflammation (4%), degeneration (4%), vascular disease (2.5%), and atrophy (2%). There was no difference in incidence of ovarian disease between controls and treated animals. The frequency of ovarian disease in mice exceeded the frequency in rats in every category.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176f/1474552/728bcdc240ac/envhper00432-0077-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176f/1474552/094fd68f4499/envhper00432-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176f/1474552/864458592c09/envhper00432-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176f/1474552/728bcdc240ac/envhper00432-0077-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176f/1474552/094fd68f4499/envhper00432-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176f/1474552/864458592c09/envhper00432-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/176f/1474552/728bcdc240ac/envhper00432-0077-c.jpg

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本文引用的文献

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Senile changes in the oestrous cycle and in ovarian structure in some inbred strains of mice.某些近交系小鼠发情周期及卵巢结构的衰老变化
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大鼠和小鼠雌性生殖系统的非增殖性和增殖性病变
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Vet Pathol. 1984 May;21(3):292-9. doi: 10.1177/030098588402100305.
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Spontaneous ovarian tumors in Han:NMRI mice: histologic classification, incidence, and influence of food restriction.Han:NMRI小鼠的自发性卵巢肿瘤：组织学分类、发病率及食物限制的影响
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