侵袭性与非侵袭性皮肤基底细胞癌中的核仁组织区

Nucleolar organizer regions in aggressive and nonaggressive basal cell carcinoma of the skin.

作者信息

De Rosa G, Staibano S, Barra E, Zeppa P, Salvatore G, Vetrani A, Palombini L

机构信息

Surgical Pathology Service, II Faculty of Medicine and Surgery, Naples, Italy.

出版信息

Cancer. 1992 Jan 1;69(1):123-6. doi: 10.1002/1097-0142(19920101)69:1<123::aid-cncr2820690122>3.0.co;2-6.

DOI:10.1002/1097-0142(19920101)69:1<123::aid-cncr2820690122>3.0.co;2-6

PMID:1727656

Abstract

Nucleolar organizer regions (NOR) were investigated on routine paraffin-embedded histologic sections of 11 aggressive basal cell carcinomas that recurred and/or metastasized (BCC2) and 11 nonaggressive basal cell carcinomas (BCC1). The absolute number of NOR per nucleus was higher in BCC2 than in BCC1, and their distribution pattern was also different. In fact, the means of argyrophilic staining of NOR (AgNOR) counts in the two groups of tumors by two observers were 6.56 with a SD of 1.98 for the nonaggressive and 9.48 with a SD of 2.12 for the aggressive basal cell carcinomas. A statistical analysis of these data using the Student's t test confirmed these observations (t = 64.49). Problems in the evaluation of NOR and possible comparison with other experiences are also discussed. The authors conclude that a quantitative assay of AgNOR and perhaps their distribution pattern may provide information useful to recognize BCC2 and hence may be of help in their prognostic prediction.

摘要

在11例复发和/或转移的侵袭性基底细胞癌（BCC2）以及11例非侵袭性基底细胞癌（BCC1）的常规石蜡包埋组织学切片上，对核仁组织区（NOR）进行了研究。BCC2中每个细胞核的NOR绝对数量高于BCC1，且它们的分布模式也不同。实际上，两位观察者对两组肿瘤中NOR（嗜银染色核仁组成区相关嗜银蛋白）计数的嗜银染色平均值，非侵袭性基底细胞癌为6.56，标准差为1.98；侵袭性基底细胞癌为9.48，标准差为2.12。使用学生t检验对这些数据进行统计分析证实了这些观察结果（t = 64.49）。还讨论了NOR评估中的问题以及与其他研究结果进行比较的可能性。作者得出结论，对嗜银染色核仁组成区相关嗜银蛋白进行定量测定，或许还有其分布模式，可能会为识别BCC2提供有用信息，从而可能有助于其预后预测。