成釉细胞瘤和基底细胞癌中核仁组织区的形态计量学研究。

Morphometric study of nucleolar organiser regions in ameloblastoma and basal cell carcinoma.

作者信息

Rosa L E, Jaeger M M, Jaeger R G

机构信息

Department of Oral Pathology, School of Dentistry, University of São Paulo, Brazil.

出版信息

Oral Oncol. 1997 May;33(3):209-14. doi: 10.1016/s0964-1955(96)00070-x.

DOI:10.1016/s0964-1955(96)00070-x

PMID:9307731

Abstract

Ameloblastoma and basal cell carcinoma share histological similarities. Morphometric analysis of nucleolar organiser regions (NORs) from ameloblastoma and basal cell carcinoma (BCC) was carried out by silver (Ag) staining. Mean counts were lower in ameloblastoma (1.652 +/- 0.032) compared to those in BCC (2.354 +/- 0.054). Ameloblastoma presented one or two NORs per nucleus, in a narrow distribution (one to four NORs per nucleus). In contrast, BCC exhibited two or three NORs per nucleus, in a broad distribution (one to six NORs per nucleus). Perimeter and area measurements of AgNOR dots yielded significantly higher mean values for ameloblastoma. Our data suggest that most BCC cells are in mitosis, showing small and numerous NORs in each nucleus, while ameloblastoma cells are in interphase, showing one or two large NORs in each nucleus. Although ameloblastoma and BCC are neoplasms with similar growth patterns, they have cell populations with statistically significant differences in AgNOR patterns.

摘要

成釉细胞瘤和基底细胞癌在组织学上有相似之处。通过银（Ag）染色对成釉细胞瘤和基底细胞癌（BCC）的核仁组织区（NORs）进行形态计量分析。与基底细胞癌（2.354±0.054）相比，成釉细胞瘤的平均计数较低（1.652±0.032）。成釉细胞瘤每个细胞核有一或两个NORs，分布狭窄（每个细胞核一至四个NORs）。相比之下，基底细胞癌每个细胞核有两个或三个NORs，分布广泛（每个细胞核一至六个NORs）。AgNOR点的周长和面积测量结果显示，成釉细胞瘤的平均值显著更高。我们的数据表明，大多数基底细胞癌细胞处于有丝分裂期，每个细胞核中有小而多的NORs，而成釉细胞瘤细胞处于间期，每个细胞核中有一或两个大的NORs。尽管成釉细胞瘤和基底细胞癌是生长模式相似的肿瘤，但它们的细胞群体在AgNOR模式上存在统计学上的显著差异。