Liu Xiaoming, Fu Yun-Xin
Human Genetics Center, School of Public Health, University of Texas, Houston, Texas 77030, USA.
Genetics. 2007 May;176(1):327-42. doi: 10.1534/genetics.106.065037. Epub 2007 Feb 4.
Longitudinal samples of DNA sequences, the DNA sequences sampled from the same population at different time points, have increasingly been used to study the evolutionary process of fast-evolving organisms, e.g., RNA virus, in recent years. We propose in this article several methods for testing genetical isochronism or detecting significant genetical heterochronism in this type of sample. These methods can be used to determine the necessary sample size and sampling interval in experimental design or to combine genetically isochronic samples for better data analysis. We investigate the properties of these test statistics, including their powers of detecting heterochronism, assuming different evolutionary processes using simulation. The possible choices and usages of these test statistics are discussed.
纵向DNA序列样本，即从同一群体在不同时间点采集的DNA序列，近年来越来越多地被用于研究快速进化生物（如RNA病毒）的进化过程。在本文中，我们提出了几种方法来检验这类样本中的遗传同步性或检测显著的遗传异时性。这些方法可用于在实验设计中确定所需的样本量和采样间隔，或合并遗传同步样本以进行更好的数据分析。我们使用模拟研究了这些检验统计量的性质，包括它们检测异时性的功效，假设了不同的进化过程。还讨论了这些检验统计量的可能选择和用法。
