Struhl Kevin
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nat Struct Mol Biol. 2007 Feb;14(2):103-5. doi: 10.1038/nsmb0207-103.
Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that 90% of Pol II initiation events in yeast represent transcriptional noise, and that the specificity of initiation is comparable to that of DNA-binding proteins and other biological processes. This emphasizes the need to develop criteria that distinguish transcriptional noise from transcription with a biological function.
真核生物转录其大部分基因组，但对于体内RNA聚合酶II转录起始的保真度了解甚少。我认为酵母中90%的Pol II起始事件代表转录噪声，并且起始的特异性与DNA结合蛋白及其他生物学过程的特异性相当。这强调了制定区分转录噪声与具有生物学功能转录的标准的必要性。
