Gu Dongfeng, Wildman Rachel P, Wu Xiqui, Reynolds Kristi, Huang Jianfeng, Chen Chung-Shiuan, He Jiang
The Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
J Hypertens. 2007 Mar;25(3):517-23. doi: 10.1097/HJH.0b013e328013e7f4.
To determine the 8-year incidence of hypertension and its risk factors among Chinese adults.
A population-based sample of 10,525 Chinese adults aged > or = 40 years and free from hypertension at baseline was followed up from 1991 to 1999-2000. Incident hypertension was defined as systolic pressure > or = 140 mmHg, diastolic pressure > or = 90 mmHg, or current use of antihypertensive medication.
Over a mean of 8.2 years of follow-up, 28.9% of men and 26.9% of women developed hypertension. Among men, independent predictors of incident hypertension were baseline age [relative risk (RR) per 5 years: 1.10; 95% confidence interval (CI): 1.07, 1.13], living in urban regions versus rural regions (RR: 0.74; 95% CI: 0.64, 0.85), alcohol drinking versus non-drinking (RR: 1.13; 95% CI: 1.02, 1.24), prehypertension versus normotension (RR: 1.70; 95% CI: 1.53, 1.88), heart rate (RR of third versus first tertile: 1.27; 95% CI: 1.13, 1.44), body mass index (RR of third versus first tertile: 1.28; 95% CI: 1.12, 1.46) and low versus high physical activity (RR: 1.27; 95% CI: 1.10, 1.47). Results were similar for women, with current smoking in place of alcohol drinking and opposite results for region. The population-attributable risk of modifiable risk factors was between 25 and 50%.
These data indicate that the incidence of hypertension is high among these Chinese adults, and suggest that 25-50% of new hypertension cases could be prevented with risk factor modification. Given the excess cardiovascular mortality associated with hypertension, these data call for urgent improvements in hypertension prevention and control programs in China.
确定中国成年人高血压的8年发病率及其危险因素。
对1991年至1999 - 2000年期间以人群为基础抽取的10525名年龄≥40岁且基线时无高血压的中国成年人进行随访。新发高血压定义为收缩压≥140 mmHg、舒张压≥90 mmHg或正在使用抗高血压药物。
在平均8.2年的随访期内,28.9%的男性和26.9%的女性患了高血压。在男性中,新发高血压的独立预测因素为基线年龄(每5年相对危险度RR:1.10;95%置信区间CI:1.07, 1.13)、城市地区与农村地区相比(RR:0.74;95% CI:0.64, 0.85)、饮酒与不饮酒相比(RR:1.13;95% CI:1.02, 1.24)、高血压前期与正常血压相比(RR:1.70;95% CI:1.53, 1.88)、心率(第三分位数与第一分位数相比的RR:1.27;95% CI:1.13, 1.44)、体重指数(第三分位数与第一分位数相比的RR:1.28;95% CI:1.12, 1.46)以及低体力活动与高体力活动相比(RR:1.27;95% CI:1.10, 1.47)。女性的结果相似,只是用当前吸烟代替饮酒,且地区的结果相反。可改变危险因素的人群归因风险在25%至50%之间。
这些数据表明这些中国成年人中高血压发病率很高,并提示通过改变危险因素可预防25% - 50%的新发高血压病例。鉴于与高血压相关的心血管死亡率过高,这些数据呼吁中国紧急改进高血压预防和控制项目。