Ponka David
Civic Campus site, Department of Family Medicine, University of Ottawa, Ontario, Canada.
Can Fam Physician. 2006 Nov;52(11):1434-8.
To present an approach to use of sulfonamide-based (sulfa) medications for patients with sulfa allergy and to explore whether sulfa medications are contraindicated for patients who require them but are allergic to them.
A search of current pharmacology textbooks and of MEDLINE from 1966 to the present using the MeSH key words "sulfonamide" and "drug sensitivity" revealed review articles, case reports, one observational study (level II evidence), and reports of consensus opinion (level III evidence).
Cross-reactivity between sulfa antibiotics and nonantibiotics is rare, but on occasion it can affect the pharmacologic and clinical management of patients with sulfa allergy.
How a physician approaches using sulfa medications for patients with sulfa allergy depends on the certainty and severity of the initial allergy, on whether alternatives are available, and on whether the contemplated agent belongs to the same category of sulfa medications (ie, antibiotic or nonantibiotic) as the initial offending agent.
介绍一种针对磺胺类药物过敏患者使用磺胺类药物的方法，并探讨对于需要使用但对其过敏的患者，磺胺类药物是否为禁忌。
使用医学主题词（MeSH）关键词“磺胺类药物”和“药物敏感性”，检索当前的药理学教科书以及1966年至今的MEDLINE数据库，结果显示有综述文章、病例报告、一项观察性研究（二级证据）以及共识意见报告（三级证据）。
磺胺类抗生素与非抗生素之间的交叉反应很少见，但偶尔会影响磺胺类药物过敏患者的药理和临床治疗。
医生如何为磺胺类药物过敏患者使用磺胺类药物，取决于初始过敏的确定性和严重程度、是否有替代药物以及拟用药物是否与初始致病药物属于同一类磺胺类药物（即抗生素或非抗生素）。
