Edelstein Peter S
Novasys Medical Inc, Newark, CA 94560, USA.
Expert Rev Med Devices. 2006 Nov;3(6):743-8. doi: 10.1586/17434440.3.6.743.
Many women with stress urinary incontinence seek a nonsurgical, well-tolerated, effective and durable treatment that is associated with a rapid recovery and improvement in quality of life. However, the nonsurgical options available, such as pelvic floor exercises or behavioral therapy, are typically not effective; thus, many women with the condition remain untreated. A new nonsurgical treatment, transurethral radiofrequency collagen remodeling, offers many patient-desired treatment characteristics. This prospective, controlled animal study was performed to evaluate the safety, gross and histological impact, and physiological effect of transurethral radiofrequency collagen remodeling. The outcomes served as the basis for initial and subsequent clinical trials in women.
许多压力性尿失禁女性寻求一种非手术、耐受性良好、有效且持久的治疗方法，这种治疗方法能带来快速康复并改善生活质量。然而，现有的非手术治疗方案，如盆底肌锻炼或行为疗法，通常效果不佳；因此，许多患有这种疾病的女性仍未得到治疗。一种新的非手术治疗方法——经尿道射频胶原重塑，具有许多患者期望的治疗特性。本前瞻性对照动物研究旨在评估经尿道射频胶原重塑的安全性、大体和组织学影响以及生理效应。这些结果为女性的初始及后续临床试验奠定了基础。
