苏黎世研究中的忧郁症和非典型抑郁症：流行病学、临床特征、病程、共病情况及人格
Melancholia and atypical depression in the Zurich study: epidemiology, clinical characteristics, course, comorbidity and personality.
作者信息
Angst J, Gamma A, Benazzi F, Ajdacic V, Rössler W
机构信息
Zurich University Psychiatric Hospital, Department of Psychiatry, Zurich, Switzerland.
出版信息
Acta Psychiatr Scand Suppl. 2007(433):72-84. doi: 10.1111/j.1600-0447.2007.00965.x.
OBJECTIVE
A comparison of psychiatric, psychological and somatic characteristics in specified subgroups of major depressive episodes (MDE).
METHOD
In a stratified community sample of young adults investigated prospectively from age 20/21 to 40/41, we defined four MDE subgroups: i) DSM-IV melancholia or atypical depression (the 'combined group'), ii) pure melancholia, iii) pure atypical depression, and iv) unspecified MDE.
RESULTS
The cumulative incidence rates of the four groups were 4.1%, 7.1%, 3.5% and 8.2% respectively. Women were over-represented in the combined and atypically depressed group. In 56 of 117 (47.9%) cases, melancholia was longitudinally associated with atypical MDE (n = 84) (OR = 11.9).
CONCLUSION
Melancholic MDE was more severe than atypical MDE although the two groups shared many characteristics. The longitudinal overlap of melancholia with atypical depression in almost half of all cases calls for comparative analyses of combined, pure and unspecified MDE.
目的
比较重度抑郁发作（MDE）特定亚组的精神、心理和躯体特征。
方法
在一个从20/21岁到40/41岁进行前瞻性调查的分层社区青年样本中，我们定义了四个MDE亚组：i）DSM-IV 中抑郁性障碍或非典型抑郁（“合并组”），ii）单纯抑郁性障碍，iii）单纯非典型抑郁，以及iv）未特定的MDE。
结果
四组的累积发病率分别为4.1%、7.1%、3.5%和8.2%。女性在合并组和非典型抑郁组中占比过高。在117例病例中的56例（47.9%）中，抑郁性障碍在纵向与非典型MDE相关（n = 84）（比值比 = 11.9）。
结论
尽管两组有许多共同特征，但抑郁性MDE比非典型MDE更严重。几乎一半病例中抑郁性障碍与非典型抑郁的纵向重叠需要对合并、单纯和未特定的MDE进行比较分析。
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