Zahra Syeda M, Whelan Thomas A, Henry Dylan, Pizarro-Campagna Elizabeth, Anderson Joel R, Yang Ying
School of Behavioural and Health Sciences, Australian Catholic University, Sydney, Australia.
School of Psychology, The Cairnmillar Institute, Hawthorn East, Australia.
Clin Psychol Psychother. 2025 Jul-Aug;32(4):e70123. doi: 10.1002/cpp.70123.
Atypical depression (AD) is one of the commonly experienced depressive subtypes and is predicted to become more prevalent despite the term 'atypical', implying that the condition is rare.
This scoping review synthesises the evidence on the manifestation and measurement of AD.
Quantitative studies published in English that mentioned atypical depression (and related terms) in adults were identified by searching the online databases CINAHL, MEDLINE Complete, PsycINFO, Scopus and Web of Science.
A total of 4498 studies were screened, and data were extracted from 56 publications (N = 139,924). During the review process, five key areas were explored: (a) unique symptomatology, (b) prevalence, (c) group differences, (d) comorbidity and factors associated with AD and (e) the use of existing measures of AD. Mood reactivity and vegetative symptoms were identified as distinct features of the subtype. AD was more common among females and young adults and comorbid with various physiological and psychological conditions. Limited information is available regarding the associated social factors. Moreover, AD is measured using limited, non-standardised, and inconsistent approaches.
Although the evidence confirms that AD is a distinct subtype of major depressive disorder (MDD), it is under-researched. Further research specifically focused on AD is now needed to gain a better understanding of psychosocial aspects of AD and develop psychometrically sound measures to enable accurate screening and diagnosis.
非典型抑郁症（AD）是常见的抑郁亚型之一，尽管“非典型”一词意味着这种情况罕见，但预计其会变得更加普遍。
本综述综合了关于非典型抑郁症表现和测量的证据。
通过检索在线数据库CINAHL、MEDLINE Complete、PsycINFO、Scopus和Web of Science，确定了以英文发表的、提及成年人非典型抑郁症（及相关术语）的定量研究。
共筛选了4498项研究，并从56篇出版物（N = 139924）中提取了数据。在综述过程中，探讨了五个关键领域：（a）独特的症状学，（b）患病率，（c）组间差异，（d）共病以及与非典型抑郁症相关的因素，（e）现有非典型抑郁症测量方法的使用。情绪反应性和躯体症状被确定为该亚型的独特特征。非典型抑郁症在女性和年轻人中更为常见，并且与各种生理和心理状况共病。关于相关社会因素的信息有限。此外，使用有限的、非标准化且不一致的方法来测量非典型抑郁症。
尽管有证据证实非典型抑郁症是重度抑郁症（MDD）的一种独特亚型，但对其研究不足。现在需要进一步专门针对非典型抑郁症的研究，以更好地了解非典型抑郁症的社会心理方面，并开发心理测量学上合理的测量方法，以实现准确的筛查和诊断。
