用于早期药物流产的米非司酮替代药物。
Alternatives to mifepristone for early medical abortion.
作者信息
Moreno-Ruiz N L, Borgatta L, Yanow S, Kapp N, Wiebe E R, Winikoff B
机构信息
Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA 02118, USA.
出版信息
Int J Gynaecol Obstet. 2007 Mar;96(3):212-8. doi: 10.1016/j.ijgo.2006.09.009. Epub 2007 Feb 5.
OBJECTIVE
To review published reports of first-trimester medical abortion regimens that do not include mifepristone.
METHODS
Reports listed in Pubmed and Medline on prospective and controlled trials of the efficacy of misoprostol, alone or associated with methotrexate, for first-trimester abortion were analyzed if they included more than 100 participants and were published since 1990.
RESULTS
The efficacy of regimens using misoprostol alone ranged from 84% to 96%, and when misoprostol was used with methotrexate the efficacy ranged from 70% to 97%. Efficacy rates were influenced by follow-up interval. Treatment for infection, bleeding, and incomplete abortion were infrequent with both methods (0.3%-5%).
CONCLUSION
Alone or in combination with methotrexate, misoprostol is an efficacious alternative to mifepristone for the medical termination of pregnancy.
目的
回顾已发表的关于不包含米非司酮的孕早期药物流产方案的报告。
方法
分析自1990年以来发表在PubMed和Medline上的有关米索前列醇单独使用或与甲氨蝶呤联合用于孕早期流产疗效的前瞻性和对照试验报告，条件是这些报告纳入了100多名参与者。
结果
单独使用米索前列醇的方案疗效为84%至96%，米索前列醇与甲氨蝶呤联合使用时疗效为70%至97%。疗效受随访间隔影响。两种方法治疗感染、出血和流产不全的情况均不常见（0.3%-5%）。
结论
米索前列醇单独使用或与甲氨蝶呤联合使用，是米非司酮用于药物终止妊娠的有效替代方法。
Zotero 插件