Xu Chun, Brennick M, Wootton D
Department of Mechanical Engineering, Drexel University, Philadelphia, PA, USA. (e-mail:
Conf Proc IEEE Eng Med Biol Soc. 2005;2005:2587-90. doi: 10.1109/IEMBS.2005.1616998.
The goal of the project is to investigate new computational tools for understanding normal upper airway mechanics and the pathophysiology of obstructive sleep apnea (OSA), a disorder characterized by repetitive pharyngeal collapse and occlusion during sleep. To relate the airway mechanical parameters to anatomy, and explore the roles of primary muscle properties, airway shape and structure, a new computational system for modeling of rat upper airway passive mechanics based on magnetic resonance imaging (MRI) was developed. The model is capable of computing stress and strain distributions under arbitrary loading, and dynamic animation of three-dimensional airway motion.
该项目的目标是研究新的计算工具，以了解正常上呼吸道力学以及阻塞性睡眠呼吸暂停（OSA）的病理生理学。OSA是一种在睡眠期间以反复咽部塌陷和阻塞为特征的疾病。为了将气道力学参数与解剖结构相关联，并探究主要肌肉特性、气道形状和结构的作用，开发了一种基于磁共振成像（MRI）对大鼠上呼吸道被动力学进行建模的新计算系统。该模型能够计算任意载荷下的应力和应变分布，以及三维气道运动的动态动画。
