Dhaliwal Sandeep S, Hesabgar Seyyed M, Haddad Seyyed M H, Ladak Hanif, Samani Abbas, Rotenberg Brian W
Department of Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.
Department of Medical Biophysics, Western University, London, Ontario, Canada.
Laryngoscope. 2018 Jan;128(1):277-282. doi: 10.1002/lary.26834. Epub 2017 Aug 23.
The use of computer simulation to develop a high-fidelity model has been proposed as a novel and cost-effective alternative to help guide therapeutic intervention in sleep apnea surgery. We describe a computer model based on patient-specific anatomy of obstructive sleep apnea (OSA) subjects wherein the percentage and sites of upper airway collapse are compared to findings on drug-induced sleep endoscopy (DISE).
Basic science computer model generation.
Three-dimensional finite element techniques were undertaken for model development in a pilot study of four OSA patients. Magnetic resonance imaging was used to capture patient anatomy and software employed to outline critical anatomical structures. A finite-element mesh was applied to the volume enclosed by each structure. Linear and hyperelastic soft-tissue properties for various subsites (tonsils, uvula, soft palate, and tongue base) were derived using an inverse finite-element technique from surgical specimens. Each model underwent computer simulation to determine the degree of displacement on various structures within the upper airway, and these findings were compared to DISE exams performed on the four study patients.
Computer simulation predictions for percentage of airway collapse and site of maximal collapse show agreement with observed results seen on endoscopic visualization.
Modeling the upper airway in OSA patients is feasible and holds promise in aiding patient-specific surgical treatment.
NA. Laryngoscope, 128:277-282, 2018.
有人提出利用计算机模拟来开发高保真模型，作为一种新颖且经济高效的替代方法，以帮助指导睡眠呼吸暂停手术的治疗干预。我们描述了一种基于阻塞性睡眠呼吸暂停（OSA）患者特定解剖结构的计算机模型，其中将上气道塌陷的百分比和部位与药物诱导睡眠内镜检查（DISE）的结果进行比较。
基础科学计算机模型生成。
在一项针对4名OSA患者的初步研究中，采用三维有限元技术进行模型开发。使用磁共振成像来获取患者的解剖结构，并使用软件勾勒出关键的解剖结构。将有限元网格应用于每个结构所包围的体积。使用逆有限元技术从手术标本中得出各个亚部位（扁桃体、悬雍垂、软腭和舌根）的线性和超弹性软组织特性。每个模型都进行了计算机模拟，以确定上气道内各种结构的位移程度，并将这些结果与对4名研究患者进行的DISE检查结果进行比较。
计算机模拟对上气道塌陷百分比和最大塌陷部位的预测与内镜观察结果一致。
对OSA患者的上气道进行建模是可行的，有望辅助针对患者的手术治疗。
无。《喉镜》，2018年，第128卷，第277 - 282页。
