Miskarova E D, Kekcheeva N G
Acta Virol. 1977 Mar;21(2):151-6.
The influence of tsutsugamushi fever infection on the metabolism of blood lymphocytes of mice differing in susceptibility to Rickettsia tsutsugamushi and of rifampicine and tetracycline treatment was studied. In susceptible mice, the activity of oxidation-reduction processes in lymphocytes increased at 7--10 days of the disease and became normal upon recovery of the animals. In mice with low susceptibility this increase of the activity began and terminated much earlier, at 3--5 days. Treatment of the infection with antibiotics resulted in a rapid arrest of the disease and normalization of the lymphocyte activity. The relationship between susceptibility of the animals to R. tsutsugamushi and the activity of oxidation-reduction enzymes is discussed on the example of succinate dehydrogenase.
研究了恙虫病立克次体感染对不同易感性小鼠血液淋巴细胞代谢的影响，以及利福平与四环素治疗的影响。在易感小鼠中，淋巴细胞氧化还原过程的活性在疾病第7 - 10天增加，动物康复后恢复正常。在低易感性小鼠中，这种活性增加开始和结束都要早得多，在第3 - 5天。用抗生素治疗感染导致疾病迅速停止，淋巴细胞活性恢复正常。以琥珀酸脱氢酶为例，讨论了动物对恙虫病立克次体的易感性与氧化还原酶活性之间的关系。
