Sauseng P, Hoppe J, Klimesch W, Gerloff C, Hummel F C
Department of Physiological Psychology, University of Salzburg, Austria.
Eur J Neurosci. 2007 Jan;25(2):587-93. doi: 10.1111/j.1460-9568.2006.05286.x.
Human brain oscillatory activity was analysed in the electroencephalographic theta frequency range (4-7 Hz) while subjects executed complex sequential finger movements with varying task difficulty and memory load. Local frontal-midline theta activity was associated with the general level of cognitive demand, with the highest amplitudes in the most demanding condition. Using low-resolution electromagnetic tomography analysis (LORETA), this theta activity was localized in the anterior cingulate gyrus including the cingulate motor area. These results suggest that local theta activity in the anterior cingulate gyrus represents correlates of an attentional system that allocate cognitive resources. In addition, interregional connectivity in the theta frequency range was modulated by memory-related executive functions independently of task difficulty. Connectivity analyses revealed a more distributed long-range network including frontal and parietal cortices during execution of novel compared with well-trained finger movement sequences. Thus, these results are compatible with a model in which theta long-range coupling indicates integration of sensory information into executive control components of complex motor behaviour.
在受试者执行具有不同任务难度和记忆负荷的复杂连续手指运动时，对脑电图θ频率范围（4 - 7Hz）内的人类大脑振荡活动进行了分析。局部额中线θ活动与认知需求的总体水平相关，在要求最高的条件下振幅最高。使用低分辨率电磁断层扫描分析（LORETA），这种θ活动定位于包括扣带回运动区在内的前扣带回。这些结果表明，前扣带回中的局部θ活动代表了分配认知资源的注意力系统的相关因素。此外，θ频率范围内的区域间连接性受与记忆相关的执行功能调节，与任务难度无关。连接性分析显示，与训练有素的手指运动序列相比，在执行新的手指运动序列时，包括额叶和顶叶皮质在内的远程网络分布更广。因此，这些结果与一个模型相符，在该模型中，θ远程耦合表明感觉信息整合到复杂运动行为的执行控制组件中。
