Marlow Laura A V, Waller Jo, Wardle Jane
Cancer Research UK Health Behaviour Unit, Department of Epidemiology and Public Health, UCL, Gower Street, 2-16 Torrington Place, London WC1E 6BT, United Kingdom.
Vaccine. 2007 Mar 1;25(11):1945-52. doi: 10.1016/j.vaccine.2007.01.059. Epub 2007 Jan 22.
To determine the acceptability of childhood HPV vaccination and examine demographic, cultural, and psychosocial predictors of vaccine acceptance.
School-based survey.
Questionnaires sent to 1205 mothers of 8-14-year-old girls. Responses from 684 were included in the analyses.
Ten schools (seven primary, three secondary) in four areas of England.
Seventy-five percent of mothers would accept the vaccine for their daughter. Vaccine acceptance was higher in mothers who had experience of cancer in the family (OR=1.61, CI: 1.14-2.29), had older daughters (OR=1.15, CI: 1.04-1.27), perceived approval from husband/partner (OR=14.51, CI: 6.15-34.25) and believed vaccine acceptance would be more normative (OR=1.78, CI: 1.59-2.01). Having concerns about too many vaccinations (OR=0.22, CI: 0.15-0.31) or vaccine side effects (OR=0.37, CI: 0.28-0.50) and worry about increasing promiscuity (OR=0.47, CI: 0.36-0.62) emerged as deterrents. The modal preferred age was 12 years. Endorsing vaccination at earlier ages was predicted by feeling able to discuss related topics, including sex, at younger ages (OR=1.37, CI: 1.24-1.51) and concern about increasing promiscuity (OR=0.61, CI: 0.47-0.78).
Overall, there was a favourable response to HPV vaccination. Emphasising the widespread acceptance of the vaccine might promote acceptance further, as would information on immunological and social benefits of earlier vaccination.
确定儿童人乳头瘤病毒(HPV)疫苗的可接受性,并研究疫苗接受度的人口统计学、文化和社会心理预测因素。
基于学校的调查。
向1205名8至14岁女孩的母亲发放问卷。分析纳入了684份回复。
英格兰四个地区的十所学校(七所小学,三所中学)。
75%的母亲会为女儿接受该疫苗。有家族癌症病史的母亲(比值比[OR]=1.61,置信区间[CI]:1.14 - 2.29)、女儿年龄较大的母亲(OR=1.15,CI:1.04 - 1.27)、认为得到丈夫/伴侣认可的母亲(OR=14.51,CI:6.15 - 34.25)以及认为疫苗接受度更具规范性的母亲(OR=1.78,CI:1.59 - 2.01)对疫苗的接受度更高。担心疫苗接种过多(OR=0.22,CI:0.15 - 0.31)、疫苗副作用(OR=0.37,CI:0.28 - 0.50)以及担心增加滥交行为(OR=0.47,CI:0.36 - 0.62)是阻碍因素。最倾向的年龄是12岁。能够在较小年龄讨论包括性在内的相关话题(OR=1.37,CI:1.24 - 1.51)以及担心增加滥交行为(OR=0.61,CI:0.47 - 0.78)预示着会更早认可疫苗接种。
总体而言,对HPV疫苗接种的反应良好。强调疫苗的广泛接受度可能会进一步促进接受度,早期接种疫苗的免疫学和社会效益信息也会有同样的效果。