Fukuda Hiroshi, Haruyama Yasuo, Nakade Makiko, Muto Takashi
Department of General Medicine, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Ind Health. 2007 Jan;45(1):56-61. doi: 10.2486/indhealth.45.56.
The purpose of this study is to determine the relationship between lifestyle and change of cardiovascular risk factors based on a five-year follow up. The subjects were 307 employees participating in annual health check-ups in Tokyo, Japan from 1998 to 2003. Personal health check-up data were collected on their systolic/diastolic blood pressure (SBP/DBP), serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), fasting serum glucose (FSG), uric acid (UA), body mass index (BMI), questionnaire on medication history and Breslow's lifestyle. Over five years, cardiovascular risk factors such as SBP/DBP, TC, TG, FBG, UA and BMI have become worse; however, some of these risk factors were significantly different after 5 yr among lifestyle groups. TG in the poor lifestyle group was significantly higher than in good or moderate lifestyle groups after adjusting for age in men. In women, SBP and BMI in poor lifestyle group were significantly higher than those in good or moderate lifestyle groups after adjusting for age and baseline values. These results show that aging is the major influencing factor of cardiovascular risk factor deterioration. At the same time, lifestyle conditions are related to changes in some cardiovascular risk factors among Japanese employees.
本研究的目的是基于五年随访确定生活方式与心血管危险因素变化之间的关系。研究对象为1998年至2003年期间在日本东京参加年度健康检查的307名员工。收集了他们的收缩压/舒张压（SBP/DBP）、血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FSG）、尿酸（UA）、体重指数（BMI）、用药史问卷和布雷斯洛生活方式等个人健康检查数据。在五年间，SBP/DBP、TC、TG、FBG、UA和BMI等心血管危险因素有所恶化；然而，在生活方式组中，其中一些危险因素在5年后存在显著差异。在男性中，调整年龄后，不良生活方式组的TG显著高于良好或中等生活方式组。在女性中，调整年龄和基线值后，不良生活方式组的SBP和BMI显著高于良好或中等生活方式组。这些结果表明，衰老心血管危险因素恶化的主要影响因素。同时，生活方式状况与日本员工某些心血管危险因素的变化有关。
