先天性免疫系统在乳腺退化重塑过程中的作用。
Roles of the innate immune system in mammary gland remodeling during involution.
作者信息
Atabai Kamran, Sheppard Dean, Werb Zena
机构信息
Lung Biology Center, Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143-2922, USA.
出版信息
J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):37-45. doi: 10.1007/s10911-007-9036-6.
Mammary gland involution is a period of intensive tissue remodeling. Over the course of a relatively brief period, a large proportion of the mammary gland epithelium undergoes programmed cell death and is removed by phagocytes. In addition, the gland is cleared of residual milk fat globules as well as milk and adipocytes become the predominant cell type. The role of the immune system in this process has not been clearly defined. Professional phagocytes derived from the immune system can participate in the clearance of apoptotic and autophagic cells, the removal of residual milk components, and the prevention of mastitis during mammary gland involution. However, many of these functions can also be performed by non-professional phagocytes (e.g. mammary epithelial cells). This review will discuss the evidence that supports a role for innate immune cells in mammary gland remodeling during involution.
乳腺退化是一个组织重塑活跃的时期。在相对较短的时间内，大部分乳腺上皮细胞经历程序性细胞死亡并被吞噬细胞清除。此外，腺体中的残留乳脂肪球被清除，乳汁被排空，脂肪细胞成为主要的细胞类型。免疫系统在这个过程中的作用尚未明确界定。源自免疫系统的专业吞噬细胞可参与乳腺退化过程中凋亡细胞和自噬细胞的清除、残留乳汁成分的清除以及乳腺炎的预防。然而，许多这些功能也可由非专业吞噬细胞（如乳腺上皮细胞）执行。本综述将讨论支持固有免疫细胞在退化过程中参与乳腺重塑的证据。
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