Menashian L, Flam M, Douglas-Paxton D, Raymond J
Corporate Cancer Services, Fresno Community Hospital and Medical Center, CA 93715.
J Am Diet Assoc. 1992 Jan;92(1):58-61.
Administration of cisplatin alone or in combination with other cytotoxic agents commonly produces intractable nausea and vomiting, which is currently controlled through high-dose antiemetic drugs. However, patients often refuse continued therapy because of suboptimal control of nausea and vomiting and substantial decline in nutritional status. In this pilot study, 19 patients receiving cisplatin were evaluated for nausea and vomiting, amount of food intake, and subjective assessment of well-being. The study group received a colorless, odorless, predetermined meal three times daily; the meal included cottage cheese, apple sauce, vanilla ice cream, and other selected foods. Control-group patients selected their own meal. Study-group patients exhibited higher overall food intake, decreased nausea and vomiting, and a higher scored estimation of well-being. The findings of this preliminary study indicate that the study diet helps provide nutrition care to cancer patients receiving cisplatin chemotherapy and helps create an atmosphere where the patient believes he or she has some control in the treatment outcome.
单独使用顺铂或与其他细胞毒性药物联合使用通常会导致难以控制的恶心和呕吐，目前通过大剂量止吐药物来控制。然而，由于恶心和呕吐控制不佳以及营养状况大幅下降，患者常常拒绝继续治疗。在这项初步研究中，对19名接受顺铂治疗的患者的恶心和呕吐情况、食物摄入量以及主观幸福感评估进行了研究。研究组患者每天三次食用无色、无味、预先确定的餐食；餐食包括农家干酪、苹果酱、香草冰淇淋和其他选定食物。对照组患者自行选择餐食。研究组患者的总体食物摄入量更高，恶心和呕吐症状减轻，对幸福感的评分更高。这项初步研究的结果表明，研究饮食有助于为接受顺铂化疗的癌症患者提供营养护理，并有助于营造一种患者认为自己对治疗结果有一定控制权的氛围。
