Ermilov Leonid G, Mantilla Carlos B, Rowley Katharine L, Sieck Gary C
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Joseph 4-184W, Rochester, Minnesota 55905, USA.
Muscle Nerve. 2007 Jun;35(6):800-3. doi: 10.1002/mus.20751.
The safety factor (SF) for neuromuscular transmission varies across limb muscles of different fiber-type composition. Using intracellular recordings in rat diaphragm fibers, we found that SF varies across muscle fiber types (even within a single muscle), being larger for type IIx or IIb fibers than for type I or IIa fibers. Fiber-type differences in activation history or mechanical load may contribute to differences in SF and are important determinants of neuromuscular plasticity.
神经肌肉传递的安全系数（SF）在不同纤维类型组成的肢体肌肉中有所不同。通过对大鼠膈肌纤维进行细胞内记录，我们发现SF在不同肌肉纤维类型之间存在差异（即使在同一块肌肉内），IIx型或IIb型纤维的SF大于I型或IIa型纤维。激活历史或机械负荷的纤维类型差异可能导致SF的差异，并且是神经肌肉可塑性的重要决定因素。
