Okuse Chiaki, Adachi Kayo, Katakura Yoshiki, Matsunaga Kotaro, Ishii Toshiya, Matsumoto Nobuyuki, Yotsuyanagi Hiroshi, Iino Shiro, Suzuki Michihiro, Itoh Fumio
Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Japan.
J Gastroenterol. 2006 Dec;41(12):1231-6. doi: 10.1007/s00535-006-1910-2. Epub 2007 Feb 6.
We present a case of deep venous thrombosis (DVT) during pegylated interferon (peg-IFN)-alpha2b plus ribavirin treatment of chronic hepatitis C (CHC). A 67-year-old man, who had been under treatment for hypertension and diabetes mellitus, was admitted to our hospital for peg-IFN-alpha2b plus ribavirin treatment for CHC. His serum hepatitis C virus (HCV) RNA level became undetectable 1 week after the initiation of peg-IFN-alpha2b plus ribavirin treatment. He suffered from severe pain, flare, and edema in both of his lower legs 6 weeks after the initiation of peg-IFN-alpha2b plus ribavirin treatment. He was diagnosed as having DVT because of the presence of a thrombus in the right soleus vein by ultrasonography. Peg-IFN-alpha2b plus ribavirin treatment was discontinued because a causal relationship between DVT and peg-IFN-alpha2b plus ribavirin treatment was suspected. DVT was not observed and the symptoms in both of his legs were improved after the administration of warfarin potassium. Subsequently, DVT has not recurred, and he has remained HCV-RNA negative.
我们报告了1例在聚乙二醇化干扰素（peg-IFN）-α2b联合利巴韦林治疗慢性丙型肝炎（CHC）期间发生的深静脉血栓形成（DVT）病例。一名67岁男性，患有高血压和糖尿病，因接受peg-IFN-α2b联合利巴韦林治疗CHC而入住我院。在开始peg-IFN-α2b联合利巴韦林治疗1周后，他的血清丙型肝炎病毒（HCV）RNA水平变得无法检测到。在开始peg-IFN-α2b联合利巴韦林治疗6周后，他双下肢出现严重疼痛、红肿和水肿。超声检查发现右比目鱼肌静脉有血栓，因此他被诊断为患有DVT。由于怀疑DVT与peg-IFN-α2b联合利巴韦林治疗之间存在因果关系，故停用了peg-IFN-α2b联合利巴韦林治疗。服用华法林钾后未观察到DVT，他双下肢的症状有所改善。随后，DVT未复发，且他一直保持HCV-RNA阴性。
