Vereerstraeten P, De Koster J P, Vereerstraeten J, Kinnaert P, Van Geertruyden J, Toussaint C
Proc Eur Dial Transplant Assoc. 1975;11:300-7.
Seventy-five pulmonary infections out of 173 kidney transplantations have been observed in 62 graft-recipients, from 1965 to 1973. The aetiologic organism is a bacteria in 80% of the cases, a fungus in 8% of the cases, cytomegalovirus and Pneumocystis Carinii in 11% of the cases. A close relationship between infection and a previous transplant crisis was noted in 66% of the cases. The most efficient diagnostic procedures were pleural and open lung biopsy as well as cultures of blood, pleural fluid and tracheobronchial secretions. Treatment was effective in 60% of bacterial and Pneumocystitis Carinii infections; on the other hand, it was less useful in fungal infections and totally ineffective in cytomegalovirus infections. Despite a possible increase in the risk of rejection, reduction or even arrest of immunosuppressive therapy is recommended in severe infections.
1965年至1973年期间，在62名肾移植受者的173例肾移植手术中观察到75例肺部感染。80%的病例中病原体为细菌，8%为真菌，11%为巨细胞病毒和卡氏肺孢子虫。66%的病例中感染与先前的移植危机密切相关。最有效的诊断方法是胸膜和开放性肺活检以及血液、胸腔积液和气管支气管分泌物培养。60%的细菌和卡氏肺孢子虫感染治疗有效；另一方面，真菌感染治疗效果较差，巨细胞病毒感染治疗完全无效。尽管排斥反应风险可能增加，但对于严重感染，建议减少甚至停止免疫抑制治疗。
