Steinmann U, Rüttner J R
Schweiz Med Wochenschr. 1977 Feb 12;107(6):178-82.
The morphological pulmonary alterations in renal transplant recipients have been investigated in the light of 62 autopsies. Apart from the predominant pulmonary edema of septic, uremic or circulatory origin, pneumonic opportunistic infections were prominent. The most important agents proved to be bacteria, cytomegalovirus and fungi. In most cases, mixed infections were observed. At autopsy, pneumocystis carinii infections appeared to be of little importance. The pathology of the pulmonary changes reflects the reduced defense inevitably following on immunosuppressive medication, which in turn is indispensable for successful transplantation.
通过62例尸检研究了肾移植受者肺部的形态学改变。除了由败血症、尿毒症或循环系统疾病引起的主要肺水肿外,肺部机会性感染也很突出。最重要的病原体是细菌、巨细胞病毒和真菌。在大多数情况下,观察到混合感染。尸检时,卡氏肺孢子虫感染似乎不太重要。肺部改变的病理学反映了免疫抑制药物治疗后不可避免的防御功能下降,而免疫抑制药物对于移植成功又是必不可少的。