Lu Zhi-bing, Jiang Hong, Yu Ying, Zhao Dong-dong, Lei Han-dong, Wang Teng, Huang Cong-xin
Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Nov;34(11):1016-20.
To investigate the relationship between sympathetic remodeling and electrical remodeling at the infarcted border zone (IBZ) of rabbit with chronic myocardial infarction (MI).
Thirty rabbits were randomly assigned into two groups: MI group (n = 20): ligation of the anterior descending coronary; sham operation (SO) group (n = 10): without contrary ligation. Eight weeks after surgery, transmural dispersion of repolarization (TDR) at baseline, during sympathetic nerve stimulation, TDR change (DeltaTDR) during sympathetic nerve stimulation and ventricular fibrillation threshold (VFT) were measured at the IBZ in MI group and corresponding zone in SO group. The distribution and densities of growth associated protein 43 (GAP43) and tyrosine hydroxylase (TH) positive nerves in ventricle were also detected with immunohistochemical techniques.
Eighteen rabbits in the MI group and 10 in the SO group survived to the end of the study. The densities of GAP43 and TH at the IBZ in the MI group were significantly higher than that at the corresponding zone in the SO group (both P < 0.05). The densities of GAP43 and TH in MI rabbits positively correlated with TDR at baseline, TDR or DeltaTDR during sympathetic nerve stimulation (all P < 0.01) and both showed a weak negative correlation with VFT (r =-0.44, P = 0.07; r = -0.41, P = 0.09, respectively).
Sympathetic remodeling is correlated with electrical remodeling at the IBZ in rabbits with chronic MI.
探讨慢性心肌梗死（MI）家兔梗死边缘区（IBZ）交感神经重构与电重构之间的关系。
30只家兔随机分为两组：MI组（n = 20）：结扎冠状动脉前降支；假手术（SO）组（n = 10）：不进行相应结扎。术后8周，测量MI组IBZ及SO组相应区域的基础跨壁复极离散度（TDR）、交感神经刺激时的TDR、交感神经刺激时TDR变化（ΔTDR）及室颤阈值（VFT）。采用免疫组化技术检测心室中生长相关蛋白43（GAP43）和酪氨酸羟化酶（TH）阳性神经的分布及密度。
MI组18只家兔和SO组10只家兔存活至研究结束。MI组IBZ处GAP43和TH的密度显著高于SO组相应区域（均P < 0.05）。MI家兔GAP43和TH的密度与基础TDR、交感神经刺激时的TDR或ΔTDR呈正相关（均P < 0.01），且两者与VFT均呈弱负相关（r = -0.44，P = 0.07；r = -0.41，P = 0.09）。
慢性MI家兔IBZ处交感神经重构与电重构相关。
