Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
J Cardiovasc Electrophysiol. 2012 Nov;23 Suppl 1:S29-35. doi: 10.1111/j.1540-8167.2012.02437.x. Epub 2012 Sep 19.
Assessment of Ventricular Electrophysiological Characteristics.
The aim of this study was to investigate the characteristics of ventricular electrophysiology following stellate ganglion block (SGB) at periinfarct zone in rabbits with myocardial infarction (MI).
Sixty-four rabbits were randomly assigned to 2 groups: MI (n = 32), ligation of the anterior descending coronary and sham operation (SO) (n = 32), without coronary ligation. Both MI and SO groups were divided into 4 subgroups according to right or left SGB and corresponding control (n = 8, each). After 8 weeks, 90% of monophasic action potential duration (MAPD90) of epicardium, midmyocardium and endocardium, transmural dispersion of repolarization (TDR), effective refractory period (ERP), and ventricular fibrillation threshold (VFT) were measured at the infarct border zone (MI group) and corresponding zone (SO group) following SGB. For SGB, 0.5 mL of 0.25% bupivacaine was used. Compared with the corresponding control group, in both the MI and SO groups, left SGB (LSGB) prolonged the MAPD90 of the 3 layers, reduced TDR, and increased ERP and VFT (P < 0.05). However, right SGB (RSGB) shortened MAPD90, increased TDR, and reduced ERP and VFT (P < 0.05).
The results of this study demonstrate that LSGB can increase the electrophysiological stability of ventricular myocardium.
摘要：本研究旨在探讨兔心肌梗死后星状神经节阻滞（SGB）对梗死周边区心室电生理特征的影响。
方法和结果：将 64 只兔子随机分为 2 组：心肌梗死（MI）组（n = 32）和假手术（SO）组（n = 32），其中 MI 组行冠状动脉前降支结扎，SO 组仅进行假手术，不进行冠状动脉结扎。MI 组和 SO 组均根据右侧或左侧 SGB 及相应对照分为 4 个亚组（每组 n = 8）。8 周后，在梗死交界区（MI 组）和相应区（SO 组）测量心外膜、中层和心内膜的单相动作电位时程（MAPD90）、复极跨室离散度（TDR）、有效不应期（ERP）和室颤阈值（VFT）。SGB 时，使用 0.25%布比卡因 0.5 mL。与相应对照组相比，左 SGB（LSGB）组 MI 和 SO 组的 3 层 MAPD90 延长，TDR 降低，ERP 和 VFT 增加（P < 0.05）。然而，右 SGB（RSGB）组 MAPD90 缩短，TDR 增加，ERP 和 VFT 降低（P < 0.05）。
结论：研究结果表明，LSGB 可增加心室心肌的电生理稳定性。
