Shen Jie-Fei, Chao Yong-Lie, Du Li
Department of Prosthodontics, West China College of Stomatology, Sichuan University, No. 14, Section 3, People's South Road, Chengdu, Sichuan 610041, China.
Neurosci Lett. 2007 Mar 26;415(2):164-8. doi: 10.1016/j.neulet.2007.01.015. Epub 2007 Jan 10.
To evaluated the effects of moderate-intensity static magnetic fields (SMF) on two types of voltage-gated potassium channel (VGPC) currents: I(K,A) and I(K,V), whole-cell patch-clamp experiments were conducted on acute dissociated rat trigeminal root ganglion (TRG) neurons. The results demonstrated that 125 mT SMF could influence the inactivation kinetics of these two VGPC currents by altering the inactivation rate and velocity. No significant change was observed in the activation properties. These findings supported the hypothesis that biological membrane would be deformed in moderate-intensity SMF and the physiological characteristics of ion channels on the membrane would be influenced. The mechanism underlying the different effects of SMF on the I(K,A) and I(K,V) inactivation was also discussed.
为评估中等强度静磁场（SMF）对两种电压门控钾通道（VGPC）电流：I(K,A)和I(K,V)的影响，对急性分离的大鼠三叉神经根节（TRG）神经元进行了全细胞膜片钳实验。结果表明，125 mT的SMF可通过改变失活速率和速度来影响这两种VGPC电流的失活动力学。激活特性未观察到显著变化。这些发现支持了以下假设：生物膜在中等强度SMF中会发生变形，膜上离子通道的生理特性会受到影响。还讨论了SMF对I(K,A)和I(K,V)失活产生不同影响的潜在机制。
