一例罕见的巨细胞骨肉瘤的细胞遗传学异常
Cytogenetic abnormalities in a rare case of giant cell osteogenic sarcoma.
作者信息
Schwartz H S, Allen G A, Chudoba I, Butler M G
机构信息
Department of Orthopedics, Vanderbilt University, Nashville, TN 37232-2550.
出版信息
Cancer Genet Cytogenet. 1992 Jan;58(1):60-5. doi: 10.1016/0165-4608(92)90135-u.
Abstract
The cytogenetic analysis of a rare, nonirradiated case of giant cell tumor of bone with osteogenic sarcoma transformation is presented for the first time in a 19-year-old female. Telomeric associations involving 4p, 8p, 11p, 14p, 17p, 17q, and 20q were observed. Additionally, monosomy 13, 11p abnormalities and marker chromosomes were identified in tumor cells. Chromosome 11 involvement, particularly 11p translocations and 11p telomeric associations, were frequently observed in the tumor cells obtained from our patient, which suggests that chromosome 11p may play a role in the development of giant cell osteogenic sarcoma.
摘要
首次报道了一名19岁女性罕见的、未经辐射的骨巨细胞瘤发生骨肉瘤转化病例的细胞遗传学分析。观察到涉及4p、8p、11p、14p、17p、17q和20q的端粒联合。此外，在肿瘤细胞中鉴定出13号染色体单体、11p异常和标记染色体。在我们患者的肿瘤细胞中经常观察到11号染色体受累，特别是11p易位和11p端粒联合，这表明11p染色体可能在巨细胞骨肉瘤的发生中起作用。
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