骨肉瘤病例中的多种细胞遗传学异常。

Multiple cytogenetic abnormalities in a case of osteosarcoma.

作者信息

Mandahl N, Heim S, Kristoffersson U, Mitelman F, Rydholm A, Rööser B, Willén H

出版信息

Cancer Genet Cytogenet. 1986 Nov;23(3):257-60. doi: 10.1016/0165-4608(86)90186-x.

Abstract

Cytogenetic analysis of a highly malignant osteosarcoma in a 17-year-old girl revealed extremely complex karyotypic changes with several different clonal numerical and structural chromosome aberrations. The composite karyotype was interpreted as 39-41,X,t(X;9)(q11;p24), -1,der(1), -4, -4, -5,i(7q),-8,del(8)(q21),t(10;19)(p13;q13),del(11)(p11p13), t(12;18)(q24;q12), -13,13q+,-14,14p+,-15,15q+,17p+,19q+,-21,+22,+3-6 mar.

摘要

对一名17岁女孩的高度恶性骨肉瘤进行细胞遗传学分析，结果显示出极其复杂的核型变化，存在几种不同的克隆性染色体数目和结构畸变。复合核型被解释为39 - 41,X,t(X;9)(q11;p24), -1,der(1), -4, -4, -5,i(7q),-8,del(8)(q21),t(10;19)(p13;q13),del(11)(p11p13), t(12;18)(q24;q12), -13,13q+,-14,14p+,-15,15q+,17p+,19q+,-21,+22,+3 - 6 mar。