妊娠性心肌病的分子机制

Molecular events underlying pregnancy-induced cardiomyopathy.

作者信息

Leinwand Leslie A

机构信息

Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

出版信息

Cell. 2007 Feb 9;128(3):437-8. doi: 10.1016/j.cell.2007.01.020.

DOI:10.1016/j.cell.2007.01.020

PMID:17289564

Abstract

The etiology of cardiomyopathy in pregnant women remains unclear. In this issue, Hilfiker-Kleiner et al. (2007) report that a reduction in STAT3 and a concomitant increase in cathepsin D may be a cause of this disease. Cathepsin D generates an antiangiogenic cleavage product of the hormone prolactin. The authors show that an inhibitor of prolactin secretion may be useful in treating this disease.

摘要

孕妇心肌病的病因仍不清楚。在本期中，希尔菲克 - 克莱纳等人（2007年）报告称，信号转导和转录激活因子3（STAT3）减少以及组织蛋白酶D相应增加可能是这种疾病的一个病因。组织蛋白酶D会产生激素催乳素的一种抗血管生成裂解产物。作者表明，催乳素分泌抑制剂可能对治疗这种疾病有用。