Davis Daniel M
Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK.
Nat Rev Immunol. 2007 Mar;7(3):238-43. doi: 10.1038/nri2020. Epub 2007 Feb 9.
Cells can extend the limits of their transcriptome by using proteins captured from other cells. Through an exchange of specific proteins, tools and information can be shared to establish integrated communities of cells that are better able to coordinate stages of an immune response. Transferred proteins can also contribute to pathology by allowing, for example, infection of cell types not otherwise infected. Here, I present the case for considering the intercellular transfer of cell-surface proteins between immune cells as commonplace and important.
细胞可以通过利用从其他细胞捕获的蛋白质来扩展其转录组的范围。通过特定蛋白质的交换，可以共享工具和信息，从而建立起能够更好地协调免疫反应各个阶段的细胞整合群落。例如，转移的蛋白质还可能通过使原本不会被感染的细胞类型受到感染而导致病理变化。在此，我提出将免疫细胞之间细胞表面蛋白质的细胞间转移视为常见且重要现象的观点。
