Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, and Veterans Affairs Medical Center, San Francisco, California, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
JCI Insight. 2018 Apr 5;3(7). doi: 10.1172/jci.insight.98942.
Extracellular RNA (exRNA) has emerged as an important transducer of intercellular communication. Advancing exRNA research promises to revolutionize biology and transform clinical practice. Recent efforts have led to cutting-edge research and expanded knowledge of this new paradigm in cell-to-cell crosstalk; however, gaps in our understanding of EV heterogeneity and exRNA diversity pose significant challenges for continued development of exRNA diagnostics and therapeutics. To unravel this complexity, the NIH convened expert teams to discuss the current state of the science, define the significant bottlenecks, and brainstorm potential solutions across the entire exRNA research field. The NIH Strategic Workshop on Extracellular RNA Transport helped identify mechanistic and clinical research opportunities for exRNA biology and provided recommendations on high priority areas of research that will advance the exRNA field.
细胞外 RNA（exRNA）已成为细胞间通讯的重要转换器。推进 exRNA 研究有望彻底改变生物学并改变临床实践。最近的努力带来了前沿研究，并扩展了我们对细胞间通讯这一新范例的认识；然而，我们对 EV 异质性和 exRNA 多样性的理解仍存在差距，这对 exRNA 诊断和治疗的持续发展构成了重大挑战。为了揭示这种复杂性，NIH 召集了专家团队讨论该领域的科学现状、确定主要瓶颈，并就整个 exRNA 研究领域的潜在解决方案进行头脑风暴。NIH 细胞外 RNA 运输战略研讨会有助于确定 exRNA 生物学的机制和临床研究机会，并就推进 exRNA 领域的优先研究领域提出了建议。
