焦虑与杏仁核。
Angst and the amygdala.
作者信息
Schulkin Jay
机构信息
Department of Physiology and Biophysics, Georgetown University, School of Medicine, Washington, DC, USA.
出版信息
Dialogues Clin Neurosci. 2006;8(4):407-16. doi: 10.31887/DCNS.2006.8.4/jschulkin.
Abstract
Fear is an adaptation to danger, but excessive fear underlies diverse forms of mental anguish and pathology. One neural site linked to a sense of adversity is the amygdala, and one neuropeptide, corticotropin-releasing hormone (CRH), is localized within the central nucleus of the amygdala. Glucocorticoids enhance the production of CRH in this region of the brain, resulting in increased attention to external events and, when sustained for longer periods of time, perhaps contributing to anxious depression.
摘要
恐惧是对危险的一种适应，但过度恐惧是多种精神痛苦和病理状态的根源。与逆境感相关的一个神经部位是杏仁核，一种神经肽，促肾上腺皮质激素释放激素（CRH），定位于杏仁核的中央核内。糖皮质激素会增强大脑该区域CRH的产生，导致对外部事件的关注度增加，而当这种状态持续较长时间时，可能会导致焦虑性抑郁。
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