用于仲醇在室温下进行动态动力学拆分的空气稳定型外消旋化催化剂。

Air-stable racemization catalyst for dynamic kinetic resolution of secondary alcohols at room temperature.

作者信息

Kim Namdu, Ko Soo-Byung, Kwon Min Serk, Kim Mahn-Joo, Park Jaiwook

机构信息

National Research Laboratory of Chirotechnology, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology (POSTECH), San 31 Hyojadong, Pohang 790-784, Korea.

出版信息

Org Lett. 2005 Sep 29;7(20):4523-6. doi: 10.1021/ol051889x.

DOI:10.1021/ol051889x

PMID:16178574

Abstract

[reaction: see text] A novel racemization catalyst was synthesized for the dynamic kinetic resolution (DKR) of alcohols with a lipase at room temperature in the air. Furthermore, a polymer-supported derivative was also synthesized and tested as a recyclable catalyst for the aerobic DKR of alcohols.

摘要

[反应：见正文] 合成了一种新型外消旋化催化剂，用于在室温空气中利用脂肪酶对醇进行动态动力学拆分（DKR）。此外，还合成了一种聚合物负载衍生物，并将其作为醇类需氧DKR的可循环催化剂进行了测试。