Watier H, Verwaerde C, Landau I, Werner E, Fontaine J, Capron A, Auriault C
Centre d'Immunologie des Maladies Transmissibles et Allergiques (Pr. Capron), Institut National de la Santé et de la Recherche Médicale U167, Institut Pasteur, Lille, France.
Infect Immun. 1992 Jan;60(1):136-42. doi: 10.1128/iai.60.1.136-142.1992.
Normal, splenectomized, and athymic Fischer rats were infected with Plasmodium chabaudi. In normal rat infections, acute-phase infection resolved rapidly and completely. In splenectomized rats, infection resulted in high parasitemia and ultimately death. In nude rats, parasite growth was reduced compared with normal rats, and a persistent parasitemia (between 20 and 45%) was observed for several months. Complete resolution of the infection was achieved after adoptive transfer of T lymphocytes, even when transfer occurred during the course of infection. These results indicated that an acquired, T-lymphocyte-dependent immunity was necessary for the complete recovery observed in normal rats. In normal rats, thrombocytopenia and splenomegaly occurred during infection. By contrast, in nude rats, both of these pathological manifestations were only observed after thymus grafting. Thrombocytopenia was also absent in the splenectomized animals. Despite an increase in platelet-associated immunoglobulin levels during the infection, thrombocytopenia was not transferred by injection of infected rat serum to normal recipients. It has been concluded that the nude rat infection can be regarded as a novel and useful model for studying the T-cell-dependent effector and pathological mechanisms and to investigate the anti-P. chabaudi immune response.
将正常、脾切除和无胸腺的费希尔大鼠感染查巴迪疟原虫。在正常大鼠感染中，急性期感染迅速且完全消退。在脾切除的大鼠中，感染导致高寄生虫血症并最终死亡。在裸鼠中，与正常大鼠相比寄生虫生长减缓，并且在几个月内观察到持续的寄生虫血症（20%至45%）。即使在感染过程中进行转移，在过继转移T淋巴细胞后感染也完全消退。这些结果表明，获得性的、T淋巴细胞依赖性免疫对于正常大鼠中观察到的完全恢复是必要的。在正常大鼠中，感染期间出现血小板减少和脾肿大。相比之下，在裸鼠中，这两种病理表现仅在胸腺移植后才观察到。脾切除的动物中也不存在血小板减少。尽管感染期间血小板相关免疫球蛋白水平升高，但通过向正常受体注射感染大鼠血清并不能转移血小板减少。得出的结论是，裸鼠感染可被视为一种新颖且有用的模型，用于研究T细胞依赖性效应和病理机制以及研究抗查巴迪疟原虫免疫反应。
