卵巢高级别恶性横纹肌样瘤对化疗有效：一例报告及文献复习
Advanced malignant rhabdoid tumor of the ovary effectively responding to chemotherapy: a case report and review of the literature.
作者信息
Banzai Chiaki, Yahata Tetsuro, Sasahara Jun, Kashima Katsunori, Fujita Kazuyuki, Nishikura Ken, Ajioka Yoichi, Motoyama Teiichi, Tanaka Kenichi
机构信息
Division of Obstetrics and Gynecology, Department of Cellular Function, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
出版信息
Gynecol Oncol. 2007 Apr;105(1):261-5. doi: 10.1016/j.ygyno.2007.01.013. Epub 2007 Feb 8.
BACKGROUND
Malignant rhabdoid tumors (MRTs) are highly malignant neoplasms that consist of both renal and extrarenal subtypes. Primary ovarian cases are extremely rare. We herein describe the third known case of ovarian origin, which effectively responded to combination chemotherapy with ifosfamide, epirubicin, and cisplatin (IEP chemotherapy).
CASE
A 19-year-old woman was diagnosed to have stage IIIc primary MRT of the ovary following the resection of tumors. Two months after surgery, an 8 cm-sized pelvic mass and enlarged retroperitoneal lymphnodes were detected. The patient received intravenous tri-weekly IEP chemotherapy. After the second course of chemotherapy, she demonstrated a complete clinical response.
CONCLUSION
Although this type of tumor is quite aggressive and chemotherapy is generally not considered to be effective, IEP chemotherapy may be useful in the treatment of MRT of the ovary.
背景
恶性横纹肌样瘤（MRTs）是一种高恶性肿瘤，包括肾型和肾外型亚型。原发性卵巢病例极为罕见。我们在此报告第三例已知的卵巢起源病例，该病例对异环磷酰胺、表柔比星和顺铂联合化疗（IEP化疗）有效。
病例
一名19岁女性在肿瘤切除后被诊断为卵巢原发性MRT IIIc期。术后两个月，发现一个8厘米大小的盆腔肿块和腹膜后淋巴结肿大。患者接受每三周一次的静脉IEP化疗。在第二个化疗疗程后，她出现了完全的临床缓解。
结论
尽管这种类型的肿瘤侵袭性很强，化疗通常被认为无效，但IEP化疗可能对卵巢MRT的治疗有用。
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