影响大肠杆菌zwf基因表达水平和生长速率依赖性调控的突变的分子特征分析。
Molecular characterization of mutations affecting expression level and growth rate-dependent regulation of the Escherichia coli zwf gene.
作者信息
Rowley D L, Fawcett W P, Wolf R E
机构信息
Department of Biological Sciences, University of Maryland Baltimore County, Catonsville 21228-5398.
出版信息
J Bacteriol. 1992 Jan;174(2):623-6. doi: 10.1128/jb.174.2.623-626.1992.
Abstract
We characterized three cis dominant mutations which elevate glucose 6-phosphate dehydrogenase level. Growth rate-dependent regulation and oxidative stress control of enzyme level were altered by the mutations. DNA sequencing and transcript mapping showed that the "up" mutations created new promoters whose hyperactive expression overrides the normal regulation of the native promoter.
摘要
我们鉴定了三个提高6-磷酸葡萄糖脱氢酶水平的顺式显性突变。这些突变改变了酶水平的生长速率依赖性调控和氧化应激控制。DNA测序和转录图谱显示，“上调”突变产生了新的启动子，其过度活跃的表达超越了天然启动子的正常调控。
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Molecular characterization of the Escherichia coli K-12 zwf gene encoding glucose 6-phosphate dehydrogenase.编码6-磷酸葡萄糖脱氢酶的大肠杆菌K-12 zwf基因的分子特征
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