内皮源性一氧化氮在高血压和肾脏疾病中的作用。
Role of endothelial-derived nitric oxide in hypertension and renal disease.
作者信息
Marin Ethan, Sessa William C
机构信息
Departments of Pharmacology and Nephrology and Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
出版信息
Curr Opin Nephrol Hypertens. 2007 Mar;16(2):105-10. doi: 10.1097/MNH.0b013e328017f893.
PURPOSE OF REVIEW
To highlight recent advances in the field of endothelial-derived nitric oxide regulation of blood pressure and renal homeostasis.
RECENT FINDINGS
Many laboratories have dissected a role for nitric oxide in regulating blood pressure and renal function. In models of hypertension, and chronic and acute renal disease, the loss of nitric oxide bioavailability may occur due to inactivation of endothelial nitric oxide synthase, synthesis of endogenous inhibitors or oxidative inactivation of nitric oxide.
SUMMARY
Understanding the molecular mechanisms of nitric oxide synthesis may lead to novel diagnostics and treatments for cardiovascular disorders.
综述目的
强调内皮源性一氧化氮在血压调节和肾脏稳态领域的最新进展。
最新发现
许多实验室已剖析了一氧化氮在调节血压和肾功能中的作用。在高血压、慢性和急性肾病模型中，一氧化氮生物利用度的丧失可能是由于内皮型一氧化氮合酶失活、内源性抑制剂的合成或一氧化氮的氧化失活所致。
总结
了解一氧化氮合成的分子机制可能会带来心血管疾病的新诊断方法和治疗方法。
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