巴西中部非洲裔巴西人隔离社区甲型肝炎病毒感染的患病率。
Prevalence of hepatitis A virus infection in Afro-Brazilian isolated communities in Central Brazil.
作者信息
Kozlowski Aline G, Motta-Castro Ana R C, Nascimento Laura B, Silva Agabo M C, Teles Sheila A, Villar Livia M, Gaspar Ana M C, Martins Regina M B
机构信息
Instituto de Patologia e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brasil.
出版信息
Mem Inst Oswaldo Cruz. 2007 Feb;102(1):121-3. doi: 10.1590/s0074-02762007000100021.
To investigate hepatitis A virus (HAV) infection rates among isolated African-descendant communities in Central Brazil, 947 subjects were interviewed about demographic characteristics in all 12 isolated Afro-descendant communities existing in the state of Mato Grosso do Sul, Central Brazil, between March 2002 and November 2003. Blood samples were collected and sera were tested for HAV antibodies (total and IgM anti-HAV) by enzyme-linked immunosorbent assay. The overall prevalence of HAV infection was 75.6% (95% CI: 72.7-78.3), ranging from 55.4 to 97.3%, depending on the communities studied. The prevalence of anti-HAV increased significantly with age, from 13.8% in the age 0-5 age group to 96.6% in those older than 40 years. The findings point out an intermediate endemicity of HAV infection in some Afro-Brazilian isolated communities in Central Brazil. In addition, the high proportion of susceptible young subjects could be target of future HAV vaccination programs.
为调查巴西中部与世隔绝的非洲裔社区中甲型肝炎病毒（HAV）的感染率，2002年3月至2003年11月期间，我们对巴西中部南马托格罗索州现有的12个与世隔绝的非洲裔社区中的947名受试者进行了人口统计学特征访谈。采集血样，并通过酶联免疫吸附测定法检测血清中的HAV抗体（总抗-HAV和IgM抗-HAV）。HAV感染的总体患病率为75.6%（95%置信区间：72.7-78.3），根据所研究的社区不同，患病率在55.4%至97.3%之间。抗-HAV的患病率随年龄显著增加，从0-5岁年龄组的13.8%增至40岁以上人群的96.6%。研究结果指出，巴西中部一些非洲裔巴西人与世隔绝的社区中HAV感染呈中度地方性流行。此外，高比例的易感年轻受试者可能成为未来HAV疫苗接种计划的目标人群。
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