巴西北部原住民中甲型肝炎的高流行率。
High prevalence of hepatitis A in indigenous population in north Brazil.
机构信息
Molecular Virology Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Federal University of Tocantins, UFT, Tocantins, Brazil.
出版信息
BMC Res Notes. 2020 Sep 29;13(1):458. doi: 10.1186/s13104-020-05303-y.
OBJECTIVES
Little is known about hepatitis A virus (HAV) prevalence in indigenous communities. This study aims to evaluate the prevalence of HAV in indigenous community compared to urban population located at Western Amazon in Brazil.
RESULTS
A total of 872 serum samples were obtained from 491 indigenous and 381 non indigenous individuals aging 0 to 90 years. Samples were tested for total and IgM anti-HAV and positive IgM samples were tested for HAV RNA. The overall prevalence of total anti-HAV was 87%, increased according age showing 100% of prevalence in those aging more than 30 years (p < 0.0001) and it was similar among indigenous and urban population. Total anti-HAV prevalence varied between tribes (p < 0.0001) and urban sites (p = 0.0014) and spatial distribution showed high prevalence in homes that received up to 100 dollars. IgM anti-HAV prevalence was 1.7% with predominance in males, those aging more than 41 years. No HAV RNA was detected. In conclusion, high overall anti-HAV prevalence was found in indigenous communities in North Brazil demonstrating the importance of universal vaccination in this group.
目的
关于甲型肝炎病毒（HAV）在原住民社区中的流行情况知之甚少。本研究旨在评估巴西西部亚马逊地区原住民社区与城市人群的 HAV 流行率。
结果
共采集了 872 份血清样本，来自 491 名原住民和 381 名非原住民个体，年龄在 0 至 90 岁之间。对所有样本进行了总抗-HAV 和 IgM 抗-HAV 检测，对阳性 IgM 样本进行了 HAV RNA 检测。总抗-HAV 的总体流行率为 87%，随着年龄的增长而增加，30 岁以上人群的流行率达到 100%（p<0.0001），且在原住民和城市人群中相似。总抗-HAV 的流行率在部落之间存在差异（p<0.0001）和城市地区之间存在差异（p=0.0014），空间分布显示，收入在 100 美元以下的家庭中流行率较高。IgM 抗-HAV 的流行率为 1.7%，男性和 41 岁以上人群中更为常见。未检测到 HAV RNA。总之，在巴西北部的原住民社区中发现了高总体抗-HAV 流行率，这表明在该人群中进行普遍疫苗接种的重要性。
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