Gonzalvez François, Gottlieb Eyal
Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow, United Kingdom.
Apoptosis. 2007 May;12(5):877-85. doi: 10.1007/s10495-007-0718-8.
Cardiolipin (CL) is a mitochondria-specific phospholipid which is known to be intimately linked with the mitochondrial bioenergetic machinery. Accumulating evidence now suggests that this unique lipid also has active roles in several of the mitochondria-dependent steps of apoptosis. CL is closely associated with cytochrome c at the outer leaflet of the mitochondrial inner membrane. This interaction makes the process of cytochrome c release from mitochondria more complex than previously assumed, requiring more than pore formation in the mitochondrial outer membrane. While CL peroxidation could be crucial for enabling cytochrome c dissociation from the mitochondrial inner membrane, cytochrome c itself catalyzes CL peroxidation. Moreover, peroxy-CL directly activates the release of cytochrome c and other apoptogenic factors from the mitochondria. CL is also directly involved in mitochondrial outer membrane permeabilization by enabling docking and activation of pro-apoptotic Bcl-2 proteins. It appears therefore that CL has multiple roles in apoptosis and that CL metabolism contributes to the complexity of the apoptotic process.
心磷脂（CL）是一种线粒体特异性磷脂，已知它与线粒体生物能量机制密切相关。现在越来越多的证据表明，这种独特的脂质在细胞凋亡的几个线粒体依赖性步骤中也发挥着积极作用。CL在线粒体内膜外小叶与细胞色素c紧密相关。这种相互作用使得细胞色素c从线粒体释放的过程比之前设想的更为复杂，这不仅需要线粒体外膜形成孔道。虽然CL过氧化作用对于使细胞色素c从线粒体内膜解离可能至关重要，但细胞色素c本身会催化CL过氧化。此外，过氧化CL直接激活细胞色素c和其他凋亡因子从线粒体的释放。CL还通过促进促凋亡Bcl-2蛋白的对接和激活直接参与线粒体外膜通透性改变。因此，似乎CL在细胞凋亡中具有多种作用，并且CL代谢促成了凋亡过程的复杂性。
