Siddiqui Anees A, Rajesh Ramadoss, Alagarsamy Veerachamy, De Clercq Erick
Department of Pharmaceutical Chemistry, Hamdard University, New Delhi, India.
Arch Pharm (Weinheim). 2007 Feb;340(2):95-102. doi: 10.1002/ardp.200600121.
A variety of novel 4-(4-substituted phenyl)-6-(4-nitrophenyl)-2-substituted imino) pyrimidines were synthesized by reacting 4-(4-substituted phenyl)-6-(4-nitrophenyl)-2-amino pyrimidines with different substituted aromatic aldehydes, coumarin chloroisatin. The 4-(4-substituted phenyl)-6-(4-nitrophenyl)-2-amino pyrimidines were synthesized by reacting 3-(4'-substituted phenyl)-1-(4-nitrophenyl)-2-propen-1-ones with guanine hydrochloride. 3-(4-Substituted phenyl)-1-(4-nitrophenyl)-2-propen-1-ones were synthesized by reacting 4-nitroacetophenone with different para-substituted aromatic aldehydes. Spectral data (IR, NMR, and mass spectra) confirmed the structures of the synthesized compounds. The synthesized compounds were investigated for their antiviral, antituberculostic, and antibacterial activities. The results of antiviral, antituberculostic, and antibacterial activities indicated that the synthesized compounds exhibited mild to potent activities compared to the respective reference standards.
通过使4-(4-取代苯基)-6-(4-硝基苯基)-2-氨基嘧啶与不同的取代芳香醛、香豆素氯靛红反应，合成了多种新型的4-(4-取代苯基)-6-(4-硝基苯基)-2-取代亚氨基嘧啶。通过使3-(4'-取代苯基)-1-(4-硝基苯基)-2-丙烯-1-酮与盐酸鸟嘌呤反应，合成了4-(4-取代苯基)-6-(4-硝基苯基)-2-氨基嘧啶。通过使4-硝基苯乙酮与不同的对取代芳香醛反应，合成了3-(4-取代苯基)-1-(4-硝基苯基)-2-丙烯-1-酮。光谱数据（红外光谱、核磁共振光谱和质谱）证实了合成化合物的结构。对合成的化合物进行了抗病毒、抗结核和抗菌活性研究。抗病毒、抗结核和抗菌活性结果表明，与各自的参考标准相比，合成的化合物表现出轻度至强效的活性。
