Deshmukh M B, Salunkhe S M, Patil D R, Anbhule P V
Department of Chemistry, Shivaji University, Kolhapur 416 004, Maharashtra, India.
Eur J Med Chem. 2009 Jun;44(6):2651-4. doi: 10.1016/j.ejmech.2008.10.018. Epub 2008 Oct 26.
The first simple and efficient approach towards one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines has been developed by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride in alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against gram-positive and gram-negative bacteria. The some of the compounds showed excellent zone of inhibition against tested bacteria.
通过芳香醛、氰基乙酸乙酯和盐酸胍在碱性乙醇中的三组分缩合反应，开发出了一种一步合成2-氨基-5-氰基-6-羟基-4-芳基嘧啶的简单高效的方法。对合成的化合物进行了针对革兰氏阳性菌和革兰氏阴性菌的抗菌活性评估。部分化合物对受试细菌显示出优异的抑菌圈。
