Ludin H P, Surber Ch
Neurologische Praxis, St. Gallen
Praxis (Bern 1994). 2006 Dec 20;95(51-52):2013-8. doi: 10.1024/1661-8157.95.51.2013.
Fluctuations (wearing-off, on off phenomenon, dyskinesias) are a big challenge in the long term treatment of parkinsonian patients. We describe the current strategies for prevention and treatment of fluctuations. Special emphasis is put on two new methods which will soon be available. The new dopamine agonist Rotigotine (Neupro) can be transdermally applied. This is a rather simple way to achieve a continuous dopaminergic stimulation. The same goal is achieved by direct application of levodopa-/carbidopa-gelsuspension (Duodopa) in the duodenum by the help of an electronic pump.
症状波动（剂末现象、开关现象、运动障碍）是帕金森病患者长期治疗中的一大挑战。我们描述了目前预防和治疗症状波动的策略。特别强调了两种即将可用的新方法。新型多巴胺激动剂罗替戈汀（Neupro）可经皮给药。这是实现持续多巴胺能刺激的一种相当简单的方法。通过借助电子泵将左旋多巴/卡比多巴凝胶悬浮液（Duodopa）直接注入十二指肠也可达到同样的目的。
